Most of the Dolpo region lies within the Himalayan rain shadow and trekking here is best done between May and October. Even though much of this region is a desert and rainfall is sparse, it’s still best to avoid the July/August period as some rain does make it over to the far side of the Himalayas.
I'd say the best time for the Dho Tarap Loop is from April to May and again from the latter half of October to November. These windows offer the most stable weather conditions and clear mountain views, making for an optimal trekking experience in this remote region.